Aeromonas hydrophila is one of the commonest causes of disease in cultivable
fishes in India. Instances of entire population of major carps getting wiped
out by epidemics of A hydrophila infection in many stocking ponds have been
reported. Immunization as a preventive measure in fish culture is gaining
popularity. The success of a vaccine depends on its antigenic composition
and the protective nature of antibodies induced. Hemolysin has been suspected
to be an important virulence factor in A. hydrophila. Therefore with the
objective of evaluating hemolysin negative derivative strain as a candidate
strain for developing a vaccine for A.hydrophila infection.
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